X-ray structures define human P2X3 receptor gating cycle and antagonist action
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چکیده
منابع مشابه
Agonist Antagonist Interactions at the Rapidly Desensitizing P2X3 Receptor
P2X3 receptors (P2XRs), as members of the purine receptor family, are deeply involved in chronic pain sensation and therefore, specific, competitive antagonists are of great interest for perspective pain management. Heretofore, Schild plot analysis has been commonly used for studying the interaction of competitive antagonists and the corresponding receptor. Unfortunately, the steady-state betwe...
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ژورنال
عنوان ژورنال: Nature
سال: 2016
ISSN: 0028-0836,1476-4687
DOI: 10.1038/nature19367